Residents living near a Leyland haulage firm say new plans for 60 homes will result in traffic chaos.
Permission was granted for a development on the Roadferry site on Carr Lane, Farington last year.
But developers have now applied to change access to the site so it is off the busy residential road of Northgate.
The application has caused uproar among residents, who say it will mean a ‘nightmare’ on the roads.
Coun Derek Forrest, who represents the Leyland Central ward at South Ribble Borough Council, is spearheading a campaign against it.
He said: “The idea of having another 120 cars coming down Northgate is not the flavour of the month to say the least.”
Outline planning permission for 60 homes on the site was granted in March 2010 but the application approved access off Carr Lane, not off Northgate.
It is now proposed that all traffic will go down Northgate and a cycle link and footpath could be built on Carr Lane.
There will also be a pedestrian footpath adjacent to Farington Business Park.
The application was recommended for approval but at a planning committee meeting at the Civic Centre on West Paddock, it was decided the decision should be deferred to a later date.
Coun Forrest said: “They have deferred the decision and in the meantime I have said to people who live nearby that we will get everyone together to talk about it.
“I think (the applicants) think the site will be more marketable if cars can drop straight down into Leyland onto Golden Hill Lane.”
Margaret Hunter, who lives on Northgate, said: “The road is congested as it is. I don’t know how we will manage with more cars on here.
“As it is, you can’t get two cars up and down together, you have to wait for someone to give way.
“What will it be like if another 100 cars are going up there?”
If passed, developers also want to introduce traffic calming measures including speed tables along Northgate at the junctions with Beech Road, Westwood Road, Hampden Road and Kennett Drive.
They also want to replace existing single yellow lines around the junction of Northgate and Golden Hill Lane with double yellow lines.
Mrs Hunter said: “I can’t see why they can’t have their access out of Wheelton Lane. It’s a nightmare.
“The traffic is mayhem and in the evening around 4pm and 5pm you can’t get out of the bottom of the street.
“I can’t see how they can do it. Everyone around here is against it.
“We are all going to get together and see what we can do about it.”
The site is owned by Roadferry Ltd and is used for warehousing and distribution.
The site is made up of industrial buildings, office space a security cabin and a maintenance building.
To the west of the site is Farington Business Park, where planning permission for 471 houses and apartments was granted permission in 2009.
The permission has not yet been implemented, although site clearance works have taken place.
The applicants could not be reached for comment before the Guardian went to press.