A collision on the A59 flyover near Penwortham has caused hold-ups for traffic heading out of Preston.
The smash happened during the rush hour and caused long tailbacks for drivers heading towards South Ribble.
One eye witness said traffic on Strand Road, Portway and Hartington Road was "extremely busy." Queues along Guild Way was said to be backing up to Corporation Street.
It is not known if there have been any casualties.